The real story behind Alzheimer’s Disease and PSEN1 скачать в хорошем качестве

The real story behind Alzheimer’s Disease and PSEN1

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. PSEN1 is a gene associated with familial Alzheimer's disease that encodes the Presenilin 1 protein. Some mutations of this gene can initiate the increased production of the toxic, longer form of amyloid-beta (Aβ) fragments. The protein encoded by this gene is the active part of gamma- (γ-) secretase, a multi-subunit protease complex is involved in the cleavage of Notch receptors, with PSEN1 participating in the release of synaptic transmitters in hippocampal vertebral neuritis. This suggests that presenilin 1 plays a critical role in the Notch signaling pathway. In this video, we discuss the current research and understanding of the PSEN1 gene and its mutation which causes familial Alzheimer's disease (FAD). More information about PSEN1 could be found at https://www.cyagen.com/us/en/communit... Neurobehavioral Platform Services for Rat and Mouse Projects could be found at https://www.cyagen.com/us/en/communit... More information about genes and diseases could be found in the Rare Disease Data Center (RDDC) https://rddc.tsinghua-gd.org/ You can find all our services on our website: www.cyagen.com/us/en/ Follow us on Social Media: Youtube:    / cyagen   Twitter:   / cyagenbio   Linkedin:   / cyagen-biosciences   Facebook: https://www.facebook.com/profile.php?... Email： [email protected] (Animal Model Services) [email protected] (Cyagen Catalog Models) [email protected] (Cell Products and Services)