TOP 3 BASIC NEUROSCIENCE PAPERS скачать в хорошем качестве

TOP 3 BASIC NEUROSCIENCE PAPERS

Functioning of NMDA receptors, dual role of Glycine and the mechanisms of excitotoxicity – the areas of Basic Neuroscience where top 3 most influential papers were published. #Neuroscience #NMDA #Excitotoxicity #Science #YuriNeuro Recently published analysis (Yeung et al., 2017) used the total number of citations and the normalized citation count (the number of scientific citation for the first ten years after the publication divided by the neuroscience citation count) to make a list of the most cited and influential papers at 6 different areas of Neuroscience: (1) neurological disorders, (2) prefrontal cortex and associated emotion/reward, (3) brain network, (4) brain mapping, (5) methodology, (6) basic neuroscience. In this video I review top 3 papers at the area of basic neuroscience based on the normalized citation count Third place is for (Johnson & Ascher, 1987) published by the neuroscientists from École normale supérieure, Paris, France. This paper revealed the allosteric binding of Glycine to the N-Methyl-D-Aspartate (NMDA) receptors. Specifically, the researchers conducted the experiments on the cultured mouse brain neurons, where they identified that Glycine, previously viewed as an inhibitory neurotransmitter, does potentiates the NMDA current. This NMDA potentiation was revealed even at the low concentrations of Glycine (10 mM) and was independent from strychnine-sensitive glycine receptors. Paper by (Johnson & Ascher, 1987) contributed to the fundamental understanding of how the NMDA receptors function (crucial for synaptic plasticity and learning and memory processes, see (Nowak et al., 1984). Second place goes to (Choi, 1988) which is a review paper assessing glutamate neurotoxicity (excitotoxicity) published by Dennis W. Choi from Stanford, the US. The paper structures and conceptualizes the knowledge about (1) classes of glutamate receptors (2) neurotoxic effect produced by the excessive amount of glutamate (3) the role of intracellular Calcium ions influx in the excitotoxicity and cell death (4) roles of excitotoxicity (neurotoxicity) in the brain injuries (e.g. strokes) and neurodegenerative disorders, such as: Alzheimer and Parkinson disorders. Also, the author discusses the perspectives and strategies for therapeutic interventions. The first place is given to (Nowak et al., 1984). In the paper the neuroscientists from École normale supérieure and Laboratoire de Neuropharmacologie, College de France demonstrated the block of NMDA receptors by Magnesium ions at the resting conditions (e.g. resting membrane potential). Due to the NMDA blockade by Mg 2+ the binding of Glutamate and Glycine (NMDA agonists), is not enough to allow the ions to pass through the channel. The opening of NMDA receptor happens when together with Glutamate and Glycine binding the depolarization of the membrane repels Magnesium ion from the channel pore. Since functioning of NMDA and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMAPA) receptors is at the basis of synaptic plasticity, and the synaptic plasticity is considered to be the driving force of the learning and memory. The paper by (Nowak et al., 1984) laid the biological foundation for understanding of learning and memory. References: Choi, D. W. (1988). Glutamate neurotoxicity and diseases of the nervous system. In Neuron. https://doi.org/10.1016/0896-6273(88)... Johnson, J. W., & Ascher, P. (1987). Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. https://doi.org/10.1038/325529a0 Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., & Prochiantz, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurones. Nature. https://doi.org/10.1038/307462a0 Yeung, A. W. K., Goto, T. K., & Leung, W. K. (2017). At the leading front of neuroscience: A bibliometric study of the 100 most-cited articles. Frontiers in Human Neuroscience. https://doi.org/10.3389/fnhum.2017.00363 Image sources: https://journals.plos.org/plosone/art... https://en.wikipedia.org/wiki/NMDA_re... https://www.talkspace.com/blog/what-i... https://www.amazon.com/NutraBulk-Glyc... - https://en.wikipedia.org/wiki/Glutama... – http://sites.bu.edu/ombs/2019/04/16/g...    • Glutamate Modulation | MOA Animation   https://psychscenehub.com/psychinsigh... https://www.cognifit.com/brain-plasti... https://singularityhub.com/2016/01/31... https://www.beliefnet.com/inspiration...    • LOTR The Fellowship of the Ring - Gandalf ...      • The Matrix Revolutions (5/5) Movie CLIP - ...      • Видео      • Видео