Pharmacology of Balofloxacin (Balomate, B-cin); Mechanism of action, Pharmacokinetics, Uses, Effects скачать в хорошем качестве

Pharmacology of Balofloxacin (Balomate, B-cin); Mechanism of action, Pharmacokinetics, Uses, Effects

Balofloxacin, marketed under names like Balomate and B-cin, is a fluoroquinolone antibiotic with a broad spectrum of activity against both gram-positive and gram-negative bacteria. Here's an overview of its pharmacology: Key Pharmacological Features: Mechanism of Action: Balofloxacin inhibits bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, and repair. This leads to bacterial cell death. Indications: It is primarily used to treat infections such as urinary tract infections (UTIs), respiratory tract infections, and skin infections. Pharmacokinetics: Absorption: Well absorbed orally. Metabolism: Primarily metabolized in the liver. Half-Life: Approximately 7 to 8 hours. Side Effects: Common side effects include nausea, dizziness, headache, and gastrointestinal disturbances. Rarely, it may cause photosensitivity or tendonitis. Contraindications: Not recommended for use in children, pregnant or breastfeeding women, or individuals with a history of hypersensitivity to fluoroquinolones #Balofloxacin