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Welcome back to The Downsized! My name is Laraine Durham, and I’ve lost more than 50 pounds on the GLP-1 medication tirzepatide. Today, we’re bringing you an incredibly important conversation—one that affects millions of women and girls but rarely gets talked about. I’m joined by Dr. Cree, a pediatric endocrinologist and leading PCOS researcher from the University of Colorado. She specializes in insulin resistance, hormone health, and the way weight intersects with PCOS across childhood, adolescence, and adulthood. In this eye-opening interview, we break down: ✔️ What PCOS actually is and why so many cases go undiagnosed ✔️ The early signs families should watch for ✔️ Why missing periods are a medical red flag, not something to ignore ✔️ How insulin resistance and weight thresholds influence PCOS symptoms ✔️ New research on low-carb diets, sleep, stress, and lifestyle ✔️ What we’re learning about GLP-1 medications (Semaglutide, Tirzepatide) in teens and women with PCOS ✔️ How weight loss—whether natural or GLP-1-assisted—can restore hormones and improve fertility ✔️ The unanswered questions about pregnancy, GLP-1s, and reproductive health ✔️ What Dr. Cree’s studies are uncovering right now ✔️ Why PCOS deserves far more research, funding, and attention from the medical community If you’re struggling with irregular periods, weight gain, insulin resistance, or suspect you might have PCOS, this is an episode you won’t want to miss. 💡 PCOS affects up to 1 in 5 women with excess weight — but only about 30% ever get diagnosed. Our goal with The Downsized is to make GLP-1 weight loss information accessible, honest, and empowering. We aren’t doctors, and this is not medical advice—always talk to your healthcare provider about your unique situation. 🎥 Recorded live on the trade show floor at ObesityWeek in Atlanta, Georgia. 00:00 Welcome to The Downsize 00:24 Introduction to Dr. Cree 00:34 Understanding PCOS 01:09 Symptoms and Diagnosis of PCOS 01:46 Impact of Weight on PCOS 02:33 Importance of Menstrual Health 05:42 Lifestyle Changes for PCOS Management 10:10 Research and Studies on GLP-1 and PCOS 16:27 Weight Loss and PCOS: The Fine Line 17:11 Metformin: Benefits and Side Effects 18:38 Personal Stories and PCOS Symptoms 19:42 Exploring GLP-1 Medications 21:03 Semaglutide vs. Tirzepatide: A Comparison 22:44 Pregnancy and GLP-1 Medications 24:42 The Need for More Research in Women's Health 31:06 Current Research and Clinical Trials 31:57 Final Thoughts and Farewell