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Question: Is increasing reactive oxygen species a good strategy for appetite control? Is that going to cause satiety in the brain? Maybe. I haven't studied that. I think Stephan Guyenet would be a great person to talk to about that. It wouldn't surprise me in the sense that if you want to shut down energy coming into the cell, why wouldn't you also want, at some bigger level, to shut down energy input into the body? I guess that makes sense. But I've mostly studied this in the case of outside the brain, peripherally, what is it doing? And what it's doing in adipose tissue or in skeletal muscle is it's shutting down glucose uptake, leading to hyperglycemia, and it's shutting down fatty acid uptake into the mitochondria leading to elevated free fatty acid levels, all of which are generally harmful to the body. Now this is an adaptively desirable thing because, let's say you have a trillion cells. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/master... and use the code QANDA to get 10% off the membership for life. Do You Have Hidden Mitochondrial Dysfunction? Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find my comprehensive mitochondrial analysis at mito.me DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.