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Non-sexually acquired genital ulcers (NSGUs) in adolescent females are uncommon, painful skin lesions on the mucous membranes of the vulva and vaginal structures, unrelated to sexual activity. NSGUs are caused by an autoimmune response following a viral illness and are unrelated to sexual activity. The lesions are often mistaken for bacterial cellulitis or lesions associated with other viral infections, such as herpes simplex virus. In this video, Stephen Scott, MD, provides an overview of how to properly identify and manage NSGUs and the timeline for healing. While the ulcers generally resolve on their own and most patients never experience another outbreak, about 25% will have subsequent occurrences. These patients require immunology or rheumatology consultations to prevent more serious and chronic autoimmune conditions, such as Behcet’s syndrome. Learn more about pediatric and adolescent gynecology at Children’s Colorado: https://www.childrenscolorado.org/doc... Connect with Children’s Colorado: Instagram: / childrenscolo Facebook: / childrenshospitalcolorado Twitter: / childrensco_pro LinkedIn: / children's-hospital-colorado Website: http://www.childrenscolorado.org