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Frontiers in Psychiatric Treatment is a webinar series designed to equip clinicians with the latest knowledge about advances in treatment through digestible, clinically relevant updates across an array of subspecialties. On June 28, René S. Kahn, MD, PhD, covered recent developments in the treatment of schizophrenia, with 15 minutes for Q&A. Dr. Kahn is the Esther and Joseph Klingenstein Professor and System Chair of Psychiatry at the Icahn School of Medicine at Mount Sinai. One of his most important contributions to science has been to help provide the scientific foundation of the century-old postulate that schizophrenia debuts with cognitive dysfunction—preceding the onset of the first psychosis by more than a decade. Moreover, he and his group have shown that brain changes in schizophrenia are progressive over time, and that these changes are clinically relevant, related as they are to outcome and to loss of cognitive function during the course of the illness. Finally, his research has shown that brain volume is one of the most heritable characteristics of man, paving the way to link brain volumes in health and disease to genetic variation.