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Dr. Thomas Seyfried is a Professor of Biology, Genetics, and Biochemistry at Boston College and a world-renowned expert in cancer biology and metabolic medicine. With a distinguished academic career spanning several decades, Dr. Seyfried has authored over 150 peer-reviewed publications in the fields of cancer research, neurobiology, lipid biochemistry, and metabolism. His work has significantly advanced our understanding of the metabolic basis of cancer, challenging traditional genetic-centric models of carcinogenesis. Dr. Seyfried is best known for his groundbreaking book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer, in which he presents compelling evidence that cancer is primarily a mitochondrial metabolic disease rather than a purely genetic one. This paradigm-shifting perspective has influenced the growing field of metabolic oncology and inspired new avenues for therapies. Professor Seyfried pages X: https://x.com/tnseyfried Instagram: / thomasseyfriedbc 00:00 Introduction 01:04 Reason behind surge of cancer and issues with conventional management 07:40 Origin of cancer 07:53 Chronic consumption of refined carbohydrates 08:09 Can cancer cells survive without glucose—only on glutamine? 08:51 Glucose, mitochondria, and cancer 11:20 Lowering risk and prevention of cancer 13:27 Inappropriate diet, processed food, and carbohydrates 14:34 Metabolic therapy in Istanbul 16:19 Why is metabolic therapy so effective? 19:33 Can we stop tumor growth by lowering blood sugar? 20:11 Correlation between tumor growth and blood sugar levels 21:50 Glucose Ketone Index (GKI) 23:58 Exercise and cancer 24:28 Diet and cancer 26:46 Is it possible to reach ketosis without a ketogenic diet? 28:02 Is there a diet that lowers glutamine? 28:21 Agents that lower glutamine and issues with conventional medicine 30:46 Is metabolic therapy more effective in certain cancer types? 32:33 Electron microscopy and mitochondria research 34:49 The nuclear–mitochondria experiment 40:25 Conversations with oncologists about Dr. Seyfried’s research and evidence 42:58 Tracking, glucose monitoring, and future technology 45:24 Aim of metabolic therapy 47:07 Intermittent fasting, lifestyle, and cancer management 53:00 Healthy people getting cancer? 54:36 Environmental toxins and cancer, organic, homegrown, and free-range food 58:04 Convenience, sedentary living, and evolutionary mismatch 59:11 Traditional, organic, free-range and locavore 01:00:59 Damaged mitochondria 01:02:15 Targeting cancer cells — what happens? 01:04:43 Case study: Pablo 01:11:30 One key study oncologists should reference 01:13:58 Clinical trials and future directions 01:15:44 Current AI in cancer 01:17:52 Hyperbaric oxygen therapy and cancer 01:18:28 Glutamine: protocols, timing, and challenges 01:20:28 Closing remarks — “When the science comes, you can’t suppress the truth.”