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Piriformis syndrome and true sciatica are often confused, but they are distinct conditions. Sciatica refers to pain radiating along the course of the sciatic nerve, which extends from the lower back through the buttock, down the back of the thigh, and into the lower leg and foot. It typically affects one side of the body and is commonly referred to as lumbar radiculopathy. The most frequent cause of sciatica is disc herniation. However, it is important to note that sciatica itself is not a diagnosis but rather a symptom of an underlying condition. For instance, in piriformis syndrome, sciatica occurs due to compression of the sciatic nerve by the piriformis muscle. In this case, the condition is diagnosed as piriformis syndrome. Conversely, if sciatica results from a herniated disc, the diagnosis is lumbar radiculopathy. This distinction is crucial in determining appropriate treatment. Piriformis syndrome is characterized by sciatic nerve symptoms due to nerve compression in the region of the buttock and hip. This condition is closely related to the piriformis muscle and its anatomical relationship with the sciatic nerve. The piriformis muscle extends from the sacrum to the hip, lying in close proximity to the sciatic nerve. The nerve exits below the piriformis and is positioned anterior to it. Several factors can contribute to piriformis syndrome, including anatomical variations such as a split piriformis muscle, vascular structures, or variations in the sciatic nerve path. Additionally, piriformis syndrome may result from muscle tightness or spasm, leading to sciatic nerve compression. Overuse activities, such as prolonged cycling, can trigger muscle tightness and inflammation, exacerbating symptoms. Clinically, patients with piriformis syndrome experience pain in the posterior gluteal region and buttock, with radiation down the back of the leg following the sciatic nerve pathway. This presents with symptoms similar to sciatica, including burning, tingling, and shooting pain. Several provocative tests can help identify piriformis syndrome. The FAIR test (Flexion, Adduction, and Internal Rotation of the hip) reproduces symptoms by increasing tension in the piriformis muscle. The Lassègue test, or straight leg raise test, exacerbates pain when forced ankle dorsiflexion is applied. Differentiating piriformis syndrome from true sciatica is essential. While both conditions may share similar symptoms, their causes differ. Diagnosis is made by excluding spinal pathology, which may be compressing the nerve root and causing sciatica. The most common cause of true sciatica is disc herniation. When a patient presents with sciatica, the physician must determine whether the compression is occurring at the sciatic nerve itself or at the nerve roots forming the sciatic nerve. An MRI is essential in ruling out spinal causes of nerve compression. If no herniated disc is found, piriformis syndrome is the likely diagnosis. Treatment of piriformis syndrome begins with conservative management, including anti-inflammatory medications, physical therapy, and piriformis stretching exercises. Injections, performed under ultrasound or fluoroscopy guidance, can provide relief. Patients should arrange for transportation following the procedure, as temporary numbness in the sciatic nerve may impair their ability to drive. Surgical intervention is considered only as a last resort. If conservative treatment fails and the patient experiences relief following a piriformis muscle injection, surgery may be warranted. Surgical options include release of the piriformis muscle and sciatic nerve neurolysis. It is crucial to confirm the diagnosis by ruling out spinal pathology and obtaining a positive response to piriformis injection before proceeding with surgery. Piriformis syndrome is ultimately a diagnosis of exclusion. Quiz Questions 1) What distinguishes piriformis syndrome from true sciatica? ✅ True sciatica is caused by nerve root compression, while piriformis syndrome results from sciatic nerve compression by the piriformis muscle. A. Both conditions are due to disc herniation. B. Piriformis syndrome is more common than true sciatica. C. Piriformis syndrome affects both sides of the body equally. D. Both conditions have the same cause. Explanation: True sciatica results from lumbar nerve root compression, while piriformis syndrome arises from direct compression of the sciatic nerve by the piriformis muscle. 2) What is the most common cause of true sciatica? ✅ Lumbar disc herniation A. Sacroiliac joint dysfunction B. Piriformis muscle spasm C. Hip arthritis D. Muscle strain Explanation: Herniated discs compressing nerve roots are the most frequent cause of true sciatica. 3) Which anatomical variation can predispose a patient to piriformis syndrome? ✅ A split piriformis muscle A. A shortened iliopsoas muscle B. A hypermobile hip joint C. A thickened sacrotuberous ligament D. An elongated sciatic nerve