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What is Langerhans Cell Histiocytosis?

Langerhans cell histiocytosis is a rare disorder that is characterized by the abnormal accumulation of Langerhans cells which form tumours called granulomas. These granulomas cause damage to organs and tissues that can lead to life threatening outcomes. About 1 out of every 200,000 children develop the disease each year. Current treatments vary depending on the severity of the condition. Since disease recurrence is common among patients, research is needed to further understand its progression in order to improve treatment plans and develop future interventions. To learn more about other rare diseases, check out the Rare Lung Diseases Series. This video was created by Julie Vo, a McMaster undergraduate thesis student in collaboration with the McMaster Demystifying Medicine Program. Special thanks to respirologists, Drs. Chong, Cox, Kolb and pathologists, Drs. Naqvi and Zafar, and members of the Ask-lab at McMaster University for their help with this project Copyright McMaster University 2021 References: Gulati, N., & Allen, C. E. (2021). Langerhans cell histiocytosis: Version 2021. Hematological Oncology, 39(S1), 15–23. https://doi.org/10.1002/hon.2857 Tazi, A. (2006). Adult pulmonary Langerhans’ cell histiocytosis. European Respiratory Journal, 27(6), 1272–1285. https://doi.org/10.1183/09031936.06.0...