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Nuclear diagnostic imaging is an area of radiology that allows physicians to see from the outside how the body is working inside. Nuclear medicine is a medical specialty that can detect gamma radiation coming from inside the patient’s body after the injection or oral administration of radiolabelled material. Thus, determining the cause of medical problems based on organ function. The development of portable gamma cameras offers new applications for intraoperative imaging. Multi-modality systems have a long heritage in nuclear medicine. A multi-model gamma-optical system has been developed for enhancing surgical utility and ultimately improving patient healthcare. The new and unique Hybrid Gamma Camera (HGC) has been designed and developed at the Space Research Centre, University of Leicester in collaboration with the University of Nottingham. The HGC is currently under clinical evaluation by investigating and imaging a number of clinical patients in the Nuclear Medicine Department at Queen’s Medical Centre, Nottingham University Hospitals NHS Trust. This novel technology is aiming to be an invaluable tool for the health care providers, particularly for surgeons, to locate tumours that need to be removed during intraoperative procedures.