Synthesis Workshop: Total Synthesis of Altemicidin with Dr. Claire Harmange Magnani (Episode 59) скачать в хорошем качестве

Synthesis Workshop: Total Synthesis of Altemicidin with Dr. Claire Harmange Magnani (Episode 59)

In this Research Spotlight episode, we're joined by Dr. Claire Harmange Magnani, who takes us through her synthetic work on the altemicidin alkaloids in the Maimone group at UC Berkeley. Key reference: J. Am. Chem. Soc. 2021, 143, 21, 7935. Other references (in order of appearance): Isolation: The Journal of Antibiotics 1989, 42, 1556 and subsequent papers. Prior syntheses: Kende et al. JACS. 1995, 117, 10597. Fukuyama et al. Org. Lett. 2014, 16, 1646. Abe et al. Nat. Commun. 2019, 10, 184. Review of dihydropyridine synthesis: Chem. Rev. 2012, 112, 2642. N-Silyl activation: JACS, 2021, 143, 6817. Erratum: The structure of AMP should have only one P=O double bond; one of the P=O bonds in the current structure should be a P-OH single bond.