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Secondary Amenorrhea Secondary amenorrhea is the absence of menstrual periods in someone who previously had regular cycles. It’s defined as: No menstruation for ≥3 months in women with previously regular cycles No menstruation for ≥6 months in women with previously irregular cycles2 🧠 Common Causes Secondary amenorrhea can result from a wide range of physiological, hormonal, and structural factors: 🔹 Physiological Pregnancy (most common cause) Lactation Menopause 🔹 Hormonal Imbalances Polycystic Ovary Syndrome (PCOS) Thyroid disorders (hypo- or hyperthyroidism) Hyperprolactinemia (often from pituitary tumors) Hypothalamic amenorrhea (due to stress, weight loss, or excessive exercise) 🔹 Medications Hormonal contraceptives (e.g., Depo-Provera) Antipsychotics or chemotherapy agents 🔹 Structural Issues Asherman’s syndrome (intrauterine adhesions from repeated D&C procedures) Ovarian failure or premature menopause 🔹 Lifestyle Factors Extreme weight changes Eating disorders (e.g., anorexia nervosa) Intense physical activity 🩺 Symptoms Absence of periods Possible signs of underlying cause (e.g., acne, hirsutism in PCOS; galactorrhea in hyperprolactinemia) Infertility or difficulty conceiving 🔍 Diagnosis Pregnancy test (always first) Hormonal profile: FSH, LH, prolactin, TSH, estradiol Pelvic ultrasound: To assess ovarian and uterine structure MRI: If pituitary tumor is suspected Endometrial biopsy: In select cases #SecondaryAmenorrhea