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The ultrasound findings of a patient with right hypochondrial pain and tenderness reveal a thickened gallbladder wall (7 mm) with moderately increased vascularity on color Doppler, suggesting active inflammation. The lumen contains particulate matter, likely sludge or debris, but no gallstones are seen. These findings strongly suggest acute acalculous cholecystitis (AAC), an inflammatory condition of the gallbladder without gallstones, often associated with critical illness, infections, or biliary stasis. Differential diagnoses include chronic cholecystitis, gallbladder wall edema from systemic causes, xanthogranulomatous cholecystitis (XGC), or empyema. Clinical correlation with fever or leukocytosis is essential, and further imaging (e.g., HIDA scan) can confirm the diagnosis. Management involves antibiotics, hydration, and possibly cholecystectomy or percutaneous cholecystostomy if the patient is critically ill. Prompt diagnosis and intervention are vital to prevent complications such as perforation or sepsis. For more on this topic visit: https://www.ultrasound-images.com/gb-... #GallbladderUltrasound #AcuteCholecystitis #AcalculousCholecystitis #RadiologyDiagnosis #BiliaryImaging #UltrasoundFindings #ColorDoppler