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#23292

Potentiating effect of tadalafil on vasodilation of the porcine superior vesical artery. Nilsson D1, Sellers D1, Chess-Williams R1 1. Centre for Urology Research, Bond University KEYWORDS: Animal Study, Basic Science, Physiology, Pharmacology An impairment in blood flow, or ischaemia of the bladder, may play a role in the aetiology of bladder storage dysfunction. Recent evidence suggests that phosphodiesterase 5 (PDE5) inhibitors may have beneficial effects in relieving ischaemia and improving urinary symptoms, by relaxing the bladder vasculature and improving blood flow (1). PDE5 expression has been reported in both the vascular smooth muscle and the endothelium of blood vessels in the human bladder (2), and a recent study has demonstrated that nitrergic vasodilatory signal transmission in the bladder vasculature underlies the therapeutic actions of PDE5 inhibitors in the rat bladder vasculature (3). The aim of this study was to determine whether the phosphodiesterase-5 inhibitor tadalafil can potentiate nitric-oxide mediated vasodilation of the porcine superior vesical artery.