Genomics and clinical data at your fingertips with open source software tranSMART & cBioPortal скачать в хорошем качестве

Genomics and clinical data at your fingertips with open source software tranSMART & cBioPortal

The CORBEL webinar series continues with a presentation by Jan-Willem Boiten, programme manager at Lygature and Menno de Vries, data manager at the Netherlands Cancer Institute. The propelling importance of genomics data in present-day health research is not yet supported with user-friendly software solutions that expose these data in a manner easily appreciated by clinical researchers. Clearly, there is a need for tools that integrate genomics and other molecular biology results with the phenotypic and clinical outcome data. This webinar presents an overview of such data tools that are used in the Dutch context and how they have been implemented in practice, including projects that are supported by CORBEL WP3. Two widely used open-source solutions specifically, tranSMART and cBioPortal, will be demonstrated: tranSMART (http://transmartfoundation.org/) is a data integration, sharing, and analysis platform for clinical and translational research. It allows users to search, view, and analyze data through a web interface, thereby allowing easy access to explore such data from multiple domains at study level. As a knowledge management platform, it enables scientists to develop and refine research hypotheses by investigating correlations between genetic and phenotypic data and assessing their analytical results in the context of other data sets. tranSMART was initially developed by Johnson&Johnson, and released as an open-source project in 2012. The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-source resource for interactive exploration of multidimensional cancer genomics data sets, currently providing access to data from more than 20,000 tumor samples from almost 100 cancer studies. It now also serves oncologists in their use and interpretation of clinical sequencing data from cancer patients and enables precision oncology. The cBioPortal software was originally developed by the Memorial Sloan Kettering Cancer Center and released as open-source in 2015. This webinar intends to give a flavor of the potential of these solutions in practical translational research. For those scientists interested in a functional and/or technical deep-dive, a CORBEL training will be scheduled for later this year. CORBEL (http://www.corbel-project.eu) is an initiative of eleven new biological and medical research infrastructures (BMS RIs), which together will create a platform for harmonised user access to biological and medical technologies, biological samples and data services required by cutting-edge biomedical research. CORBEL will boost the efficiency, productivity and impact of European biomedical research. The CORBEL webinar series aims to address challenges and share best practice between biological and medical research infrastructures. The series is aimed at technical operators of RIs and is aligned with the CORBEL competency framework. CORBEL webinars include an audience Q&A session during which attendees can ask questions and make suggestions. This webinar took place on 4th June 2019 and is part of the CORBEL webinar series. It is best viewed in full screen mode using Google Chrome. The slides from this webinar can be downloaded from SlideShare: https://www.slideshare.net/corbel-pro... For previous and upcoming CORBEL webinars see: http://www.corbel-project.eu/webinars