Genetic Variation Behind Papillary Verrucous Carcinoma скачать в хорошем качестве

Genetic Variation Behind Papillary Verrucous Carcinoma

Link : www.genedent.com Narration by : Geetika Raj ( Scientific Co-ordinator at Kroynas ) What is papillary verrucous carcinoma? Papillary verrucous carcinoma (PVC) is a rare type of cancer that affects the surface tissues of the body, such as the skin and lining of the mouth, throat, and genital area. It is characterized by slow-growing, wart-like growths that can eventually become cancerous. PVC is considered a variant of squamous cell carcinoma (SCC), which is the second most common type of skin cancer. What are its causes? The exact cause of PVC is not known, but it is believed to be related to exposure to certain environmental factors, such as ultraviolet (UV) radiation from the sun, and infection with human papillomavirus (HPV). Other risk factors include a weakened immune system, tobacco use, and exposure to certain chemicals. What are the genes behind it? There is limited research on the genetic basis of PVC, but studies have identified mutations in various genes that are involved in the development and progression of squamous cell carcinomas. These genes include TP53, PTEN, NOTCH1, and CDKN2A. What are its clinical symptoms? PVC typically appears as a small, raised growth that may have a rough or scaly surface. The growth may be pink or red in color, and may have a wart-like appearance. As the growth progresses, it may become larger and more invasive, and may develop into a sore or ulcer. PVC can occur on any part of the body, but is most commonly found on the feet, hands, or genital area. What is its treatment? Treatment for PVC typically involves surgical removal of the affected tissue, along with radiation therapy and/or chemotherapy. In some cases, a combination of these treatments may be used. The specific treatment approach will depend on the size and location of the growth, as well as the stage of the cancer. Prognosis for PVC is generally good if the cancer is detected and treated early.