GI Biopsy Studies in Autism – Frederico Balzola, MD, Molinette University Hospital @Synchrony2020 скачать в хорошем качестве

GI Biopsy Studies in Autism – Frederico Balzola, MD, Molinette University Hospital @Synchrony2020

The increased prevalence of gastrointestinal symptoms in patients with autism compared to healthy controls has been extensively proved, with a potential secondary impact on children’s behaviours. From a physiopathological point of view, dysbiosis associated to impaired gastrointestinal permeability have been suggested as possible triggers thus altering the normal nervous system functions. Dietary or pharmacological interventions are often utilized, however, results are still debated. In this uncertain context, the existence of a possible link between gastrointestinal inflammation and neuropsychiatric disorders need to be clarified in the way to find the right dietetic and pharmacological tools to obtain the best effects on bowel and neurological inflammatory process and for this reason improvement of gastrointestinal and autistic symptoms. Our study confirmed the high prevalence of gastrointestinal symptoms and pathological microscopic histological alterations in 339 patients with autism that underwent upper and lower endoscopy with biopsies in our unit. A significant association between clinical manifestations and histological alterations has been identified with a significant improvement of clinical and neuropsychiatric symptoms after dietetic and pharmacological treatment of the intestinal inflammation. Further controlled prospective studies are required in order to confirm these correlations and permit to treat this category of patients at the very early onset of gastrointestinal symptoms in the way to obtain better clinical results unfortunately nor reachable if later attempted for the natural achievement of the complete altered neurological development. This talk was part of Synchrony 2020 Online Symposium - 'From Bench to Biopharma', organised by the The BRAIN Foundation in partnership with UC Davis MIND Institute and CalTech. For more Synchrony 2020 talks and highlights:    • Synchrony Symposium 2020 - From Bench To B...   🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 Synchrony https://synchronysymposium.com/ is the first and only international symposium on translational research in #autism, that brings together academia, #biotech, pharmaceutical companies and #venture partners from around the world with the mission to improve health and quality of life of people with #autismspectrumdisorder. 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 The BRAIN Foundation https://brainfoundation.org/ is a 501c(3) non-profit. The founders of BRAIN envision a world where every child and adult on the autism spectrum is healthy, participates fully in education and employment, and has a better quality of life. It aims to catalyze research that results in evidence-based interventions for the disabilities associated with autism, and also results in better medical standard of care. To accomplish this, it funds impactful research through #philanthropy and our network of partners in the venture, corporate, and grassroots community.