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Think Outside the Box: A Unique Approach to the Management of Comorbid Malignant Pleural and Pericardial Effusions A 42-year-old man with recently diagnosed stage IV lung adenocarcinoma presented to the hospital with dyspnea and presyncope. During his index hospitalization earlier that year, he presented with pericardial tamponade. He was found to have extensive pleural/pericardial metastasis and had previously undergone both a left thoracoscopic pericardial window and placement of a left basilar indwelling pleural catheter (IPC) for outpatient effusion management. In the emergency department during this visit, he was found to be hypotensive with pulsus paradoxus and echocardiographic findings suggestive of a recalcitrant episode of tamponade (Video 1). His IPC was additionally found to be dysfunctional due to pleurodesis of the surrounding pleura, and CT scan demonstrated interval development of a multiloculated pleural effusion and moderate pericardial effusion. What's the diagnosis? Read the full article in the September issue of #journal_CHESTPulm: https://hubs.la/Q03JFh0p0 #MedEd #JournalCHEST