Webinar: Multiscale model of the different modes of cancer cell invasion: a PhysiBoSS application скачать в хорошем качестве

Webinar: Multiscale model of the different modes of cancer cell invasion: a PhysiBoSS application

The tumour microenvironment encompasses many different cell types including cancer cells, stromal cells, immune cells, and the extracellular matrix (ECM), that interact and collectively influence cancer progression and treatment outcomes. Recently, computational mathematical models have been proved efficient in testing hypotheses and giving insights about tumour microenvironment functionalities. Among those, hybrid multiscale models combine different techniques that simulate both inter- and intra-cellular interactions. In this context, we present a 3D model of cancer cell invasion, aiming to study the different modes of cell migration through the extracellular matrix and to predict means to block it by considering spatial information, molecules’ diffusion and intracellular regulation. The model was constructed using PhysiBoSS, a multiscale framework, which combines agent-based modelling and continuous time Markov processes applied on Boolean network models. Our multiscale model successfully reproduces single and collective migration processes reported in published experiments on cell invasion. These experiments include various aspects such as the role of p63 expression in regulating MT1-MMP, the spatio-temporal activation of SRC triggering collective migration, and the influence of different collagen densities on invasion modes. In silico experiments can be performed to suggest potential targets capable of inhibiting highly invasive tumour phenotypes. Speaker: Marco Ruscone, Institut Curie All materials are free cultural works licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, except where further licensing details are provided.