Lab Med and Pathology Research & Discovery Seminar | Eduard Reznik скачать в хорошем качестве

Lab Med and Pathology Research & Discovery Seminar | Eduard Reznik

"Travels in a Metabolic No-Man's Land" Eduard Reznik, PhD Assistant Member, Computational Oncology Service Memorial Sloan Kettering Cancer Center Why Attend this Seminar? My research group uses computational methods to address basic and translational questions concerning the metabolism of tumors. We live in a strange, two-fold no-man's land. We speak neither the language of the cancer genomicists, nor that of our experimental metabolism colleagues. We want to learn about data-scarce metabolic flux, but are largely restricted to correlative analyses of more abundant genomic, transcriptomic, and steady-state metabolomic data. In this talk, I'll guide you through our approach to these challenges in the context of our lab's two long term research efforts relating to (1) the function of somatic changes to mitochondrial DNA in cancer and (2) the identification and function of recurrent metabolic adaptations in tumors. Chapters: 0:00 - Introduction by Dr. Alexander Mendenhall 0:30 - Dr. Reznik's Presentation 51:57 - Q&A