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Imagine finding the Holy Grail on a dusty shelf. This video delves into drug repurposing, a promising approach that saves time and cost by using approved medications for new diseases. We explore temozolomide, our main weapon against the aggressive brain cancer glioblastoma - its synthesis, mechanism and why it just barely extends survival. New research shows antidepressants like vortioxetine might have value as add-on therapies. Could this unexpected duo be the next step or even cure in the fight against glioblastoma? https://total-synthesis.com/organic-c... 🧑🎓➡️ Free organic chemistry practice problems / totalsynthesis 🚀 Thanks to all channel supporters!!! / totalsynthesis_official 👉 Follow me on Instagram to follow updates on other random chemistry research and interesting news! https://total-synthesis.com/ 00:00 A cure to glioblastoma? Video overview 00:42 Drug repurposing or repositioning 02:27 The blood brain barrier 03:19 Glioblastoma, the worst (brain) cancer? 04:30 Chemotherapy for glioblastoma 05:08 Temozolomide is explosive 06:12 The big problem 06:46 Pls sub, thx 07:03 Mechanism of action of temozolomide 10:25 MGMT, the key enzyme 13:25 Pharmaceuticals as diazomethane surrogates? 14:11 Can antidepressants cure brain cancer? Methodology 16:55 Vortioxetine and its promising effects 19:13 No self-medication 19:42 Mibefradil, an interesting wild card 20:09 CAR-T in glioblastoma (chimeric antigen receptor T-cells) 21:19 Thanks for watching! Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. Key references: -- High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity | Nat Med (2024). https://doi.org/10.1038/s41591-024-03... Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond | Nat Rev Drug Discov. 2006, 5, 689 Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives | Cancers 2022, 14, 443 Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial | Lancet Oncology 2009, 10, 459 Importance of Thermal Stability Data to Avoid Dangerous Reagents: Temozolomide Case Study | Org. Process Res. Dev. 2021, 25, 1690 O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas | Cell Death and Disease 2013, 4, e876 Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma | J Clin Oncol 2010, 28, 4601 Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture | ACS Chemical Biology 2022, 17, 299 Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations | Angew Chem Int Ed Engl 2020, 59, 1857 Antidepressants and survival in glioma—A registry-based retrospective cohort study | Neuro-Oncology Practice 2024, 11, 125 Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug | Cell Reports 2021, 37, 109957