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📝 All videos on Renal Physiology: https://www.nonstopneuron.com/post/ph... 🌐 Explore our entire animation video library: https://www.nonstopneuron.com/ ● Follow me at: • Instagram: / nonstopneuron • Facebook: / nonstopneuron Urea Recycling | Role of Urea in Kidney | Urea Excretion | Urea Handling by Nephrons: From the thick ascending limb to the outer medullary collecting duct, the tubule is impermeable to urea. Now, when your body water decreases, your pituitary gland secretes antidiuretic hormone. It increases the water reabsorption, from the collecting duct. As urea is not reabsorbed from here, the water reabsorption alone, increases the urea concentration, in the lumen. So it starts getting reabsorbed at the inner medullary collecting duct. This initiates a cycle, that accumulates more and more urea, in the interstitium. This allows you to excrete urea, at higher concentrations. So the requirement for urine volume decreases. The osmolarity in the inner medulla can reach up to 1200 during this. However, urea contributes to osmolarity, only at the inner medulla. It does not contribute to osmolarity in the outer medulla, even during this. Now, when you drink enough water, the ADH level falls. Without water reabsorption, the urea does not get concentrated. So urea in the tubule is excreted in urine right away. Previously accumulated urea in the interstitium is washed out by capillaries, or, excreted in urine. During this, the osmolarity at the inner medulla falls to 600. Chapters: 00:00 Introduction 00:21 Urea Concentration in Different Sites 00:41 Urea Recycling 03:37 Control of Urea Recycling 06:11 Importance of Urea Recycling 08:41 Corticomedullary Differentiation 09:41 Summary 11:14 Bonus Point Dr Vipul Navadiya Nonstop Neuron Medical Animation Medical Animation Videos Physiology water permeability of nephron sodium reabsorption role of vasopressin in urea concentration DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.