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What Causes Poor Conversion of T4 To T3?

It’s no surprise that the majority of people with thyroid disease suffer with ongoing thyroid symptoms and ongoing visits to the doctor or endocrinologist. Much of this has do with a thyroid conversion problems leading to low T3. If one month your thyroid levels are up then the next month your thyroid levels are down, you are probably suffering with some kind of T4-3 conversion issue resulting in Low T3. If the conversion of T4 to T3 is poor, then you will experience many of the common hypothyroid symptoms. Symptoms of Low T3 Fatigue, Depression Sensitivity to cold temperatures, Brain Fog (difficulty concentrating/Focusing) Weight gain. Hair Loss Keep in mind, that this poor conversion of T4 into T3 can occur even if your TSH levels appear to be normal and in range. The modern approach is to be aware of the various abnormal body function patterns and the underlying physiological mechanisms that can cause the other 6 patterns of thyroid trouble. Hypothyroidism The first pattern is primary hypothyroidism. In this case the thyroid gland gets sort of lazy and the pituitary gland rushes in by pumping extra TSH (thyroid stimulating hormone) in an attempt prompt the thyroid to produce more thyroid hormones. Primary hypothyroidism affects the entire body. A person may begin to feel sluggish, though there are various symptoms that can occur. Low TSH In the second pattern the TSH will be low but not as low as with primary hypothyroidism. The pituitary gland, through various mechanisms, fails to produce proper quantities of TSH and so the thyroid gland is not stimulated adequately to produce T4 and T3. A common way that this occurs is from chronic stress. Chronic stress fatigues the pituitary gland. Under Conversion The third pattern is thyroid under conversion. This is when the gland is making enough T4 but the conversion to T3 is inadequate and therefore there is low T3. The reason for this can be chronic infection or inflammation. Increased cortisol from the adrenal gland that is responding to stress from a chronic infection may also cause this. High cortisol is also toxic to the temporal lobe of the brain, causing poor memory and mental fogginess. This pattern is often missed because low T3 doesn’t affect TSH levels and T3 is rarely checked for with the standard blood tests performed by medical physicians. A clue to this pattern is that all other thyroid tests are normal except for T3. Immune system The third pattern is the immune system, which usually fights infection, attacks the thyroid gland. This damages the thyroid, which means it's not able to make enough of the hormone thyroxine, leading to the symptoms of an underactive thyroid. A condition called Hashimoto's disease is the most common type of autoimmune reaction that causes an underactive thyroid. Thyroid Resistance The fifth pattern is thyroid resistance. Chronic stress is the root cause of thyroid resistance. Chronic stress stimulates the adrenal glands, which in turn produces far too much cortisol. High levels of cortisol from the adrenal gland cause cells throughout the body to become resistant to thyroid hormones. The pituitary and thyroid are all right, but the hormones are not getting into the cells. Thyroid Binding Globulin (TGB) Elevation The sixth pattern is Thyroid Binding Globulin (TGB) elevation. This is when there is too much TGB in the blood and too little T3. When TBG is too high it is like having too many taxi cabs for T3 hormone and the cabs won’t let out their passenger for fear that they won’t get another! This is mainly caused by oral contraceptives. Oral contraceptives, or estrogen replacement therapy, cause an increase in estrogen which then leads to increases in TBG. Can I help You? -Click the link to schedule Your consultation: www.totalwellnessdupage.com Email: [email protected] Dr. Jinaan Jawad 26W276 Geneva Road Suite C Carol Stream, IL 60188 630-653-2225 Visit Us: https://www.totalhealthdupage.com/ https://www.totalwellnessdupage.com/ Facebook:   / totalhealth06   Instagram:   / wellnesstot.  . DR. JINAAN JAWAD D.C., DACNB, FACFN, FIAMA, CFMP Dr. Jawad is a Board Certified Chiropractic Neurologist and Acupuncturist. In addition, a Diplomat for the American Chiropractic Neurology Board, Fellow of the American College of Functional Neurology as well as Fellow of the International Academy of Medical Acupuncture. He is a Certified Functional Medicine Practitioner. Any information on diseases and treatments available at this channel is intended for general guidance only and must never be considered a substitute for advice provided by a doctor or other qualified healthcare professional. Always seek the advice of your physician or other qualified health care professional with questions you may have regarding your medical condition.