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Tags: Agriculture, Contaminants, Disease, Mold, Powdery Mildew Cultivation of Cannabis sativa L. (marijuana) plants has increased the incidence and severity of previously unreported diseases. Hydroponically-grown and field-grown plants are susceptible to infection by root, foliar and flower-infecting pathogens. The causal agents of browning and rotting of roots were identified as species of Pythium and Fusarium by PCR and sequence analysis of the ITS region. A rot of the flower buds was associated with Botrytis cinerea, as well as Penicillium olsonii, and to a lesser extent, P. copticola, causing penicillium bud rot. Powdery mildew was found to be caused by Golovinomyces (Erysiphe) cichoracearum sensu. The pathogen was detected on vegetatively propagated cuttings. These cannabis pathogens can reduce product quality and disease management practices need to be established. Promising biological control agents and nonfungicide products are being assessed on cannabis. In addition, use of disease-free plants as starting material and sanitation practices and water management should reduce disease outbreaks. Avoidance of wounding to the roots and inclusion of disease-suppressive planting mixes are recommended. Management of powdery mildew remains a challenge and biocontrol and nonfungicide products are being assessed.