[Lemonex] BALLkine-2: A new-age IL-2-DegradaBALL for targeted, non-toxic cancer immunotherapy скачать в хорошем качестве

[Lemonex] BALLkine-2: A new-age IL-2-DegradaBALL for targeted, non-toxic cancer immunotherapy

[Lemonex] Recent strategies in cancer immunotherapy based on interleukin-2 (IL-2) are generally focused on reducing regulatory T cell (Treg) development by modifying IL-2 receptor alpha (IL-2Rα) domain. However, the clinical utility of high-dose IL-2 treatment is mainly limited by severe systemic toxicity. We find that peritumorally injectable ‘BALLkine-2’, recombinant human IL-2 (rIL-2) loaded porous nanoparticle, dramatically reduces systemic side effects of rIL-2 by minimizing systemic IL-2 exposure. Notably, in cynomolgus monkeys, subcutaneous (SC)-injection of BALLkine-2 not only dramatically reduces systemic circulation of rIL-2 in the blood, but also increases half-life of IL-2 compared to IV- or SC-injection of free rIL-2. Peritumorally-injected BALLkine-2 enhances intratumoral lymphocyte infiltration without inducing Treg development and more effectively synergizes with PD-1 blockade than high-dose rIL-2 administration in B16F10 melanoma model. BALLkine-2 could be a highly potent therapeutic option due to higher anti-tumor efficacy with lower and fewer doses and reduced systemic toxicity compared to systemic rIL-2. #RNA #oncology #vaccine #platform #nanobiotechnology #레모넥스 #디그래더볼 #Lemonex #DegradaBALL #DNA #drugdeliverysystem #immunotherapy #dds #drugs #medicine #ios #immunology #therapy #antibody #nano #injection #virus #genetherapy #pharmacology #delivery #development #tcell #cell #science #chemistry #lnp #mrna #siRNA #delivery