Identifying new treatments for patients with appendix cancers: Professors Omer Aziz and Pat Caswell скачать в хорошем качестве

Identifying new treatments for patients with appendix cancers: Professors Omer Aziz and Pat Caswell

Pseudomyxoma peritonei (PMP) is a condition that arises because of the metastasis from a low-grade appendiceal mucinous neoplasm (LAMN) – a rare appendix tumour with an estimated incidence of only 1-2 cases per million - which spreads into the abdominal (peritoneal) cavity. This causes an accumulation of a large amount of solid and liquid mucinous material causing abdominal distension (swelling), malnutrition and ultimately mortality. Previously, PMP has been treated through aggressive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), but despite these interventions, over 30% of cases of PMP recur. At present, there is no standard anti-cancer treatment or targeted treatment available for this rare tumour. We speak to Professors Omer Aziz and Pat Caswell about new treatments for patients with appendix cancers, covering the work we are doing here in Manchester such as work Pat is focused on which is establishing organoids for use in discovering treatment options for appendiceal mucinous neoplasms.