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Summary Multiple studies have shown that most patients who receive chimeric antigen receptor (CAR) T-cell therapy report a good quality of life long-term. Learn how CAR T-cell therapy is performed and its short-term and long-term effects on patients and caregivers. Discover key differences between CAR T-cell, stem cell transplant and other and chemotherapy treatments. Presenter: Patrick Connor Johnson MD, Massachusetts General Hospital Cancer Center Many thanks to Kite, a Gilead Company whose support helped make this Survivorship Symposium possible. To read the transcripts, go to: https://bmtinfonet.org/video/quality-... Highlights (02:57): The cancers discussed in this talk are blood cancers that are very good at hiding from the immune system, which is normally able to clear abnormal cells from the body. (05:40): CAR T-cell therapy is truly a personalized treatment. Instead of prescribing a drug to fight cancer, CAR T-cells are a living drug. (07:51): CAR T-cell therapy is approved by the Food and Drug Administration (FDA) for patients with - lymphoma, multiple myeloma, or acute leukemia. treatments. (10:53): CAR T-cell Therapy is different than traditional chemotherapy, so the side effects are different. Common side effects include cytokine release syndrome (CRS), neurologic or brain toxicity, low blood counts, low immunoglobulins and infections. (14:54): Quality of life decreases two weeks after CAR T-cell therapy but, on average, improves by 3-6 months after CAR T-cell therapy (15:49): Psychological symptoms – anxiety, depression and even post-traumatic stress disorder (PTSD) – are common during CAR T-cell therapy. These symptoms generally improve by six months after CAR T-cell therapy. (18:56): Usually the patient and caregiver are required to stay within 30 minutes to two hours from the hospital for the first month after CAR T-cell therapy so they can be monitored closely. (25:06): Long-term survivorship involves multiple things: cognitive function, physical function, psychological function and looking for other cancers and new conditions. (26:41): Quality of life outcomes long-term appear good, based on research to date. (29:37): A caregiver is required to stay with the patient for the first 30 days after treatment – primarily to identify and report potential complications quickly so that they can be managed promptly. This can be stressful for caregivers. April 2024, Part of the Virtual Celebrating a Second Chance at Life Survivorship Symposium 2024 Presentation is 40 minutes long with 19 minutes of Q & A. Key Points Quality of life and symptom burden generally improve over time after CAR-T cell therapy. CAR-T survivors have quality of life similar to the general population. Caregivers of patients receiving CAR-T may experience significant psychological symptoms. Meet the speaker: https://www.massgeneral.org/doctors/2... VISIT US ON SOCIAL MEDIA: / bmtinfonet / bonemarrowstemcelltransplantclub / bmtinfonet https://x.com/BMTInfoNet / bmt-infonet