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Reference: https://www.videogie.org/article/S246... The effective management of a significantly large stone located in the common hepatic duct of a patient who has undergone pancreaticoduodenectomy presents a unique set of challenges. In this case, the integration of advanced techniques such as cholangioscopy and electrohydraulic lithotripsy proved to be instrumental in addressing the obstruction caused by the stone. Cholangioscopy allows for direct visualization of the biliary tree, enabling the physician to accurately assess the size and location of the stone, which is crucial for planning the subsequent intervention. This minimally invasive approach not only enhances diagnostic capabilities but also facilitates targeted treatment strategies. Electrohydraulic lithotripsy, a technique that utilizes high-energy shock waves to fragment stones, was employed to effectively break down the large stone into smaller, more manageable pieces. This method is particularly advantageous in cases where traditional methods may be less effective due to the size or location of the stone. By utilizing this technology in conjunction with cholangioscopy, the medical team was able to ensure a thorough and efficient removal process, minimizing the risk of complications and promoting a quicker recovery for the patient. The combination of these advanced techniques underscores the importance of innovation in surgical practices, particularly in complex cases. The successful resolution of this case not only highlights the efficacy of cholangioscopy and electrohydraulic lithotripsy in managing large common hepatic duct stones but also emphasizes the need for a multidisciplinary approach in treating patients with a history of pancreaticoduodenectomy. Such cases require careful consideration of the patient's unique anatomical and physiological circumstances, as well as the potential for complications arising from previous surgeries. The positive outcome achieved in this instance serves as a testament to the advancements in endoscopic techniques and their role in enhancing patient care, ultimately leading to improved surgical outcomes and patient satisfaction.