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🛑 Summary of eye embryology 👸👩🏫 ✍️ 22 day ☝️ Optic groove appears ✍️ 25 day ☝️ optic vesicle forms optic groove ✍️ 26 day ☝️ superior rectus ☝️ inferior rectus ☝️ medial rectus ☝️ inferior oblique ✍️ 27 day ☝️ Formation of lens plate from surface ectoderm ☝️ lateral rectus ✍️ 28 day ☝️ Embryonic fissure forms ☝️ Cells presumed to become retinal pigment epithelium acquire pigmentation ✍️ 29 day ☝️ superior oblique ✍️ 5th week ☝️ Lens pit forms and deepens into lens vesicle ☝️ Hyaloid vessels develop ☝️ Primary vitreous develops ☝️ Osseous structures of the orbit begin to develop ✍️ 6th week ☝️ Closure of embryonic fissure ☝️ Corneal epithelial cells develop interconnections ☝️ Differentiation of retinal pigment epithelium ☝️ Proliferation of neural retinal cells ☝️ Formation of secondary vitreous ☝️ Formation of primary lens fibers ☝️ Development of periocular vasculature ☝️ Appearance of eyelid folds and nasolacrimal duct ☝️ Ciliary ganglion appears ✍️ 7th week ☝️ Migration of ganglion cells toward optic disc ☝️ Formation of embryonic lens nucleus ☝️ Development of choroidal vessels from periocular mesenchyme ☝️ Three waves of neural crest migration • first wave: formation of corneal and trabecular endothelium • second wave: formation of corneal stroma • third wave: formation of iris stroma ☝️ Formation of tunica vasculosa lentis ☝️ Sclera begins to form ✍️ 3rd month ☝️ Differentiation of precursors of rods and cones ☝️ Ciliary body develops ☝️ Appearance of limbus ☝️ Anterior chamber appears as a potential space ☝️ Sclera condenses ☝️ Eyelid folds lengthen and fuse ✍️ 4th month ☝️ Formation of retinal vasculature begins ☝️ Beginning of regression of hyaloid vessels ☝️ Formation of physiologic cup of optic disc ☝️ Formation of lamina cribrosa ☝️ Major arterial circle of iris forms ☝️ Development of iris sphincter muscle ☝️ Development of longitudinal ciliary muscle and processes of ciliary body ☝️ Formation of tertiary vitreous ☝️ Bowman’s membrane forms ☝️ Canal of Schlemm appears ☝️ Eyelid glands and cilia form ✍️ 5th month ☝️ Photoreceptors differentiate ☝️ Eyelid separation begins ✍️ 6th month ☝️ Cones differentiate ☝️ Ganglion cells thicken in macula ☝️ Differentiation of dilator pupillae muscle ☝️ Nasolacrimal system becomes patent ✍️ 7th month ☝️ Rods differentiate ☝️ Ora serrata forms ☝️ Migration of ganglion cells to form nerve fiber layer of Henle ☝️ Choroid becomes pigmented ☝️ Circular ciliary muscle fibers develop ☝️ Myelination of optic nerve ☝️ Posterior movement of anterior chamber angle ☝️ Orbicularis muscle differentiation ✍️ 8th month ☝️ Completion of anterior chamber angle formation ☝️ Hyaloid vessels disappear ✍️ 9th month ☝️ Retinal vessels reach the temporal periphery ☝️Pupillary membrane disappears ✍️ within 3 month after delivery ☝️ Development and maturity of macula #embryology #optometry #oculardevelopment #eyeballdevelopment #ophthalmogy #sightalright