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Known to most of his friends as Holly, Dr. Lloyd Hollingsworth Smith Jr. joins Ushma Neill, JCI Editor at Large, for the next in the journal's series Conversations with Giants in Medicine. He talks about leading the University of California, San Francisco, Department of Medicine, as its chairman for 21 years. During his tenure, Dr. Smith transformed the department to the preeminent West coast medical school with the highest standards in patient care, teaching, and research. He talks about his early days training in Boston, and about his experiences getting the first artificial kidney to work, both in the hospital and in the Korean War. Citation: J Clin Invest. 2012;122(6):1949--1950. doi:10.1172/JCI64561 Summary transcript: http://www.jci.org/articles/view/64561