Serotonin Receptors | Types of Serotonin Receptors and Serotonin Receptor Pharmacology скачать в хорошем качестве

Serotonin Receptors | Types of Serotonin Receptors and Serotonin Receptor Pharmacology

This video focuses on the serotonin receptors and their molecular biology, pharmacology, and psychological effects when stimulated. Serotonin (also known as 5-hydroxytryptamine or 5-HT) is a neurotransmitter molecule used in a huge variety of neurobiological processes. There are 14 different 5-HT receptors in the brain and body, each with a fairly unique intracellular signaling mechanism and distinct psychological effects. What do you think of Sense of Mind’s new style (more visuals, shorter videos)? Let me know in the comments. This is the first in a miniseries on the neurobiology of the serotonin system. Link to the rest of the serotonin videos:    • Serotonin Miniseries   Chapters: 00:00 Serotonin (5-HT) is NOT just the happiness molecule 00:35 The goals and approach of this video and miniseries on serotonin 01:36 This is a new style for Sense of Mind’s neuroscience videos 02:18 Part 1: Mechanism of serotonin synaptic transmission 03:05 How SSRIs work 03:28 The “need-to-know” of synaptic transmission 03:57 Serotonin is a “neuromodulator” that can work extra synaptically 04:44 Part 2: Families and subtypes of 5-HT receptors 05:20 Most 5-HT receptors are GPCRs 06:00 5-HT1 and 5 receptor inhibitory mechanisms 06:30 5-HT2, 4, 6, and 7 receptors excitatory mechanisms 07:02 5-HT3 receptor excitatory mechanism 07:33 Please sign up for the video newsletter and podcast! 08:16 Part 3: What do the different receptors do to the brain? 09:28 Some effects of stimulating 5-HT receptors in the human brain 10:28 Resolving some paradoxes of 5-HT pharmacology (presynaptic receptors and biased agonism) 12:25 Examples of bodily effects of 5-HT stimulation 13:10 How can one neurotransmitter do so much? 13:59 Conclusion: Some remaining questions 14:35 - Please like and subscribe! Thank you! – Sign up for the weekly video newsletter: http://senseofmindshow.com/newsletter/ And subscribe to the podcast (new episode every week!): https://anchor.fm/senseofmind Follow us on Instagram:   / sense.ofmind   And Facebook:   / senseofmindshow   – Sources Cited: 1. Sharp, T., & Barnes, N. M. (2020). Central 5-HT receptors and their function; present and future. Neuropharmacology, 177, 108155. https://pubmed.ncbi.nlm.nih.gov/32522... 2. Di Giovanni, G., & De Deurwaerdère, P. (2020). Serotonin research: Crossing scales and boundaries. https://doi.org/10.1016/j.neuropharm.... 3. Hoyer, D. (2020). Targeting the 5-HT system: Potential side effects. Neuropharmacology, 108233. https://pubmed.ncbi.nlm.nih.gov/32805... 4. Mosienko, V., Bader, M., & Alenina, N. (2020). The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models. In Handbook of Behavioral Neuroscience (Vol. 31, pp. 601-607). Elsevier. 5. Carhart-Harris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 1091-1120. https://pubmed.ncbi.nlm.nih.gov/28858... 6. Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., ... & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. International journal of molecular sciences, 21(5), 1649. https://pubmed.ncbi.nlm.nih.gov/32121... 7. Carvajal-Oliveros, A., & Campusano, J. M. (2021). Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?. Frontiers in Behavioral Neuroscience, 14, 262. https://www.frontiersin.org/articles/... 8. Dingman M. Know Your Brain: Raphe Nuclei. Neuroscientifically Challenged. https://neuroscientificallychallenged.... Published October 27, 2017. 9. JJ Medicine. “Serotonin and Melatonin Synthesis | Tryptophan Metabolism”    • Serotonin and Melatonin Synthesis | Trypto...  .