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If you’re taking oral Levodopa—like Sinemet, Rytary, or Crexont—this video is for you. Dr. Zayas, a neurologist specializing in Parkinson’s disease and movement disorders, breaks down the 6 most common side effects of Levodopa that every patient should know. 💡 Important Note: This video isn’t against Levodopa! In fact, as of 2025, there’s no better medication by mouth to treat Parkinson’s disease (PD). However, understanding its potential side effects is crucial for better management. 🔍 What You’ll Learn in This Video: 1. Nausea: The most common side effect for new users, occurring in 20% of patients. Most cases resolve on their own, but some patients struggle to tolerate Levodopa. Watch my detailed video on managing nausea here. • Nausea in Parkinson's due to Sinemet ... 2. Orthostatic Hypotension: Learn what it is and how to manage it effectively, especially if you experience low blood pressure. Link to my video about managing low blood pressure in PD is in the description. • Drop in blood pressure in Parkinson's... 3. Exacerbating Psychosis: This rare side effect can happen in certain cases. I discuss the causes and treatment in another video (link below). • How to Treat Hallucinations in Parkin... 4. Dyskinesias: Understand when and why these involuntary movements occur. How to treat dyskinesias in Parkinson' s Disease? link: • How to treat dyskinesias in Parkinson... 5. Daytime Sleepiness: Levodopa can worsen sleepiness in some patients, but this is manageable with proper care. 6. Impulse Control Disorders (ICD): Rare but significant, ICDs include pathological gambling, hypersexuality, and binge eating, affecting less than 5% of patients. 💪 Key Takeaway: Levodopa remains the gold standard for PD treatment. It’s not toxic, and there’s no reason to fear it. The only thing that compares to Levodopa’s effectiveness is high-intensity exercise. If I had PD, I’d take Levodopa alongside a robust exercise routine—just like my current training for a 5k race this April 2025! 📢 Subscribe for More: If you found this video helpful, hit the subscribe button to stay updated on Parkinson’s disease tips, treatments, and expert insights. I hope you like this video and find it helpful. For more information, visit our website: https://www.gemneurology.com/ Dr. Z Luis E. Zayas, MD PT GEM Neurology PLLC, Clinton, TN Board-certified internist and neurologist by the American Board of Internal Medicine and the American Board of Psychiatry and Neurology. Fellowship trained in Movement Disorders and Neuro Critical Care. *Former New Jersey and Puerto Rico licensed physical therapist.