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Abstract: New advanced endosonographic techniques have only been introduced recently and will be demonstrated in this video sequence using the pancreatic organ as a target. The aim of these new techniques is to provide more information about a certain lesion in order to differentiate these lesions into benign and malignant. Although definitive differentiation is still a matter of histology, these new techniques are able to greatly increase the chance of correct diagnosis. Elastography is a technique which allows the estimation of the hardness of a lesion. The major problem of the technique is, however, that a hard structure is not necessarily malignant. Contrast-enhanced high mechanical index color Doppler endosonography was introduced shortly after the development of the ultrasound contrast enhancer. It provides the endosonographist vital information about the macrovessel system of the pancreas and can therefore discriminate inflammatory from malignant pancreatic lesions with a high degree of certainty. Contrast-enhanced low mechanical index endosonography is newly introduced into clinical practice and can display the vascularization of pancreatic microvessels. Because there are some cancerous lesions with an intact microvessel system, the degree of certainty is not as high as the high mechanical index version; however, it is still useful for clinical practice. The best results with the method can be achieved by using it for discrimination of cystic pancreatic lesions because of the excellent resolution of the method. Both methods can be used for a simultaneous three-dimensional (3D) reconstruction. The 3D reconstruction helps to mark the outlines of a lesion, and the data can be used to scroll through the lesion after the procedure is finished. This article is part of an expert video encyclopedia. READ THE FULL ARTICLE ON OUR OPEN ACCESS VIDEO JOURNAL & ENCYCLOPEDIA HERE: http://www.sciencedirect.com/science/... #endoscopic #ultrasound #pancreatitis #EUS #Elastography #endosonography #3D #reconstruction #video #endoscopy #Elsevier #VJGIEN #openaccess #journal #pancreas #carcinoma