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This Perspective discusses how chemical species can serve as inputs to supramolecular devices so that a luminescence output is created in a conditional manner. Conditionality is built into these devices by employing the classical photochemical process of photoinduced electron transfer (PET) to compete with luminescence emission. The response of these devices in the analogue regime leads to sensors that can operate in nanometric, micrometric, and millimetric spaces. Some of these devices serve in membrane science, cell physiology, and medical diagnostics. The response in the digital regime leads to Boolean logic gates. Some of these find application in improving aspects of medical diagnostics and in identifying small objects in large populations. Subscribe! http://bit.ly/AmerChemSOc Facebook! / journalofphysicalchemistry Twitter! / jphyschem For more information, please visit the Journal of Physical Chemistry Letters website: https://pubs.acs.org/journal/jpclcd You might also like: ACS Energy Letters Perspectives & Reviews: • Molecular Layer Deposition for Energy Conv... ACS Nanotation: • High-Efficiency Fog Collector: Water Unidi... Publishing Your Research 101 Series: • PYR101: George Whitesides - How to Write a... Produced by the American Chemical Society, the world’s largest scientific society. ACS is a global leader in providing access to chemistry-related information and research through its multiple databases, peer-reviewed journals and scientific conferences. Join the American Chemical Society! https://bit.ly/Join_ACS