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In this lecture I discuss Methods of Causality assessment. Various basis of casualty determination. As well as grading of casualty of ADR. MCQ on Causality Assessment also discuss. The causality assessment for adverse drug reactions (ADRs) is challenging, and none of the diferent method available for assessing the causality of ADR is accepted as the gold standard. • The causality assessment of adverse drug reactions by updated Logistic method and Naranjo algorithm are less prone to subjective variations compared to the World Health Organization-Uppsala Monitoring Center (WHOUMC) system. • Though WHO-UMC causality assessment method is easy, other objective methods like Narango algoritm and updated logistic method should be used in combination with WHO-UMC method to reduce the subjective variability. Causality assessment remains a valuable approach in pharmacovigilance to detect a causal link between an adverse event and a drug treatment. Various types of tools or assessment methods are available to assess the causal relationship between a drug and an adverse event which are broadly based on three main approaches namely expert judgement or global introspection, algorithm-based approaches, and probabilistic or Bayesian approaches Causality assessment methods like Swedish method, World Health Organization-Uppsala Monitoring Centre (WHOUMC) system are based on expert judgement. Naranjo, Karch and Lasagna, French, Kramer, Begaud, Jone, Maria and Victorino, RousselUclaf causality assessment method (RUCAM) are algorithm based causality assessment methods. Australian, Bayesian Adverse Reactions Diagnostic Instrument (BARDI), MacBARDI and the recently developed updated Logistic method are based on probabilistic or Bayesian approach. Though various methods are used for causality assessment of adverse drug reactions (ADRs), none of the methods is accepted as the best for analyzing the causality and each method has its own advantages and limitations. WHO-UMC method is used as practice tool for reporting of individual adverse event reports by the national centers participating under International Drug Monitoring Program. Likewise, Naranjo algorithm, which was initially developed for adverse event monitoring in clinical trial, is also used by healthcare professional for assessing adverse events. The pharmaceuticeutical industries use these methods for initial case processing but the fnal reports are given to the regulatory authorities in binary terms like ‘related’ or ‘not related’. The WHO-UMC system is a universally accepted method for causality assessment. Although it is comparatively easy for analysis and less time consuming, at the same time several disadvantages have been described, such as high dependency on individual expertise and judgement for assessment, weak and poor reproducibility in the WHOUMC system, and moreover individual categories are not sharply delineated. Naranjo algorithm is rather simple and brief. It is the most extensively used method discerning scores for each point which reduce intra and inter-observer variation and had good reproducibility. But the disadvantages of this method are lack of sensitivity for the ‘uncertain’ category resulting in low score for certain type of ADRs, not valid in children, not appropriate to use in critically ill patients, organ toxicities, drug overdose, and drug–drug interactions . The probabilistic approach, based on Bayesian theorem provides results in the form of probability of causation of an adverse event. Although regarded as the most reliable approach, the methods used based on this approach are not suitable for routine practice because these are complex and time-consuming . In 2006 Researchers reported a new method of causality assessment known as the Logistic method based on the probabilistic approach which was again updated in 2012. Although comparisons among various methods are mentioned in many articles, the comparison among Logistic methods and other methods are mentioned in very few articles. WHOUMC causality assessment system takes into account the clinical-pharmacological aspect , whereas the Naranjo algorithm assigns scores to these aspects, such as temporality and alternative explanations, as well as to the responses to additional questions. Though there are some published articles comparing WHO-UMC system and Naranjo algorithm , comparison among WHO-UMC system, Naranjoalgorithm and updated Logistic method are lacking. Various playlist of our Channel Anitmicrobial agent Pharmacology • Tetracycline ADR & Uses Mnemonics by using... Human Anatomy & Physiology Lectures Playlist • Kidney Function (Hindi)|| Why We Need Kidn... FACEBOOK: / vivekjainsir INSTAGRAM: / tutorbox3 You tube Channel Link: / tutorboxchannel .