Reprogramming the Brain Tumor Microenvironment to Enhance Anti-Tumor Immunity скачать в хорошем качестве

Reprogramming the Brain Tumor Microenvironment to Enhance Anti-Tumor Immunity

Achieving effective and sustainable anti-tumor immunity remains a significant challenge in cancer therapy, largely due to tumor immunosuppression. This is particularly pronounced in brain tumors, which create one of the most immunosuppressive tumor microenvironments. A key player in this process are macrophages, which can shift between a pro-inflammatory M1-like state and a pro-tumor M2-like state, contributing to the suppression of immune responses. In this webinar, we present the latest research on reprogramming the brain tumor microenvironment to enhance anti-tumor immunity. Using advanced spatial tissue analysis combined with in vitro experiments, we will delve into the mechanisms regulating macrophage-dependent tumor immunosuppression in brain cancer. Our findings reveal that the spatial localization of macrophages within the tumor microenvironment influences their functional state, and that pathological tissue remodeling within perivascular niches impacts the activity of tumor-infiltrating lymphocytes. Key Topics Include: Impact of the brain tumor microenvironment on immune cells The role of macrophages in tumor immunosuppression How tissue remodeling could enhance anti-tumor immunity in brain cancer To learn more, go to: https://insidescientific.com/webinar/...