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In this episode of the Veterinary Vertex Podcast, we break down a recent randomized, double-blinded clinical trial published in JAVMA that asks a surprisingly practical question: does replacing the needle before subcutaneous vaccination in dogs actually make a difference? Needle replacement is a common habit in veterinary medicine, often assumed to reduce pain or improve the patient experience. This study put that assumption to the test by comparing physiologic and behavioral responses in dogs receiving routine vaccines with and without needle replacement. We walk through the study design, what the data showed, and why researchers Jane Sagaser and Dr. Rachael Kreisler concluded there was no measurable clinical benefit to switching needles before injection. We also talk about what these findings mean for day-to-day workflow, efficiency, cost, and evidence-based decision-making in veterinary practice. If you enjoy digging into the research behind everyday clinical habits, this episode is for you. JAVMA article: https://doi.org/10.2460/javma.25.10.0661