What Is PT-141? How It Works (And Why It's Not Like Viagra) скачать в хорошем качестве

What Is PT-141? How It Works (And Why It's Not Like Viagra)

#PT141 #Peptides #SexualHealth Viagra and Cialis work on blood flow. They amplify a signal that is already there. But what if the signal itself is the problem? PT-141 is a peptide that works in your brain on the circuits that generate desire, and it has Phase 3 clinical trial data in over 1,200 patients showing it works for both men and women. And the mechanism is completely different from anything else out there. In this video I walk you through exactly how PT-141 works in your brain, what the clinical research shows for both men and women, how it compares to Viagra and Cialis, and what you can realistically expect if you try it. You'll learn about: 🔬 How PT-141 activates MC4 receptors in your hypothalamus to trigger dopamine and generate desire upstream in the brain 💊 Why PT-141 is fundamentally different from Viagra and Cialis and who it actually helps 👩 The RECONNECT Phase 3 trial data in 1,247 women showing 58% meaningful improvement vs 35% on placebo 👨 The clinical evidence in men, including Viagra non-responders who went from 6 minutes to 41 minutes of rigidity ⚠️ The 40% nausea rate, how to manage it, and why it is the main barrier to using this peptide 📋 Exact dosing, timing, frequency limits, and the drug interactions you need to know about before starting ⚕️ Disclaimer: This video is for informational purposes only and not medical advice. Always consult your physician before starting any peptide protocol. 📑 Chapters 00:00:00 Introduction 00:01:25 How PT-141 Works in Your Brain 00:03:10 Why It's Different from Viagra and Cialis 00:03:47 PT-141 vs MT2: What I Simplified 00:04:46 Clinical Evidence in Women (RECONNECT Trials) 00:06:18 Clinical Evidence in Men 00:07:22 Combining PT-141 with Viagra or Cialis 00:08:07 Side Effects from the Trials 00:08:36 Dosing, Timing, and Frequency 00:09:40 Why the Effects Outlast the Drug 00:10:23 What To Expect and Managing Nausea 00:11:27 Safety and Drug Interactions 00:12:12 Summary 00:12:47 Outro 📲 Free Peptide & Supplement Tracker App: https://tracker.joshholyfield.com 🏛️ Join my FREE Skool community: For men: https://www.skool.com/jh-iron-forge-b... For women: https://www.skool.com/powerhouse-pept... 🎯 Looking for personalized coaching and accountability? https://programs.theironforge.us/survey Drop your questions in the comments and subscribe for more real-world insights on peptides and sexual health. ____________________ Socials: Facebook:   / joshholyfieldpd   Instagram:   / josh.holyfield   TikTok:   / josh_holyfield   Youtube:    / joshholyfieldfitness   Blog: https://joshholyfield.com/blogs/news ====================================================== Josh Holyfield - For all business inquiries contact josh@joshholyfield.com This video is not to be reproduced without prior authorization. The original YouTube video may be distributed & embedded if required. 📚 References 1. Clayton AH et al. The Neurobiology of Bremelanotide for HSDD. CNS Spectrums. 2021. https://pubmed.ncbi.nlm.nih.gov/33455... 2. Van der Ploeg LH et al. A Role for the MC4 Receptor in Sexual Function. PNAS. 2002. https://pubmed.ncbi.nlm.nih.gov/12172... 3. Kingsberg SA et al. Bremelanotide for HSDD: Two Phase 3 Trials. Obstetrics and Gynecology. 2019. https://pubmed.ncbi.nlm.nih.gov/31599... 4. Simon JA et al. Long-Term Safety and Efficacy of Bremelanotide for HSDD. Obstetrics and Gynecology. 2019. https://pubmed.ncbi.nlm.nih.gov/31599... 5. Rosen RC et al. Subcutaneous PT-141 in Healthy Males and Viagra Non-Responders. Int J Impotence Research. 2004. https://www.nature.com/articles/3901200 6. Goldstein S, Goldstein I. Bremelanotide in Men with Sexual Dysfunctions. J Sexual Medicine. 2024. https://academic.oup.com/jsm/article/... 7. Diamond LE et al. Co-administration of PT-141 and Sildenafil in Men with ED. Urology. 2005. https://pubmed.ncbi.nlm.nih.gov/15833... 8. Clayton AH et al. Bremelanotide Dose-Finding Trial in Premenopausal Women. Women's Health. 2016. https://pubmed.ncbi.nlm.nih.gov/27181... 9. Clayton AH et al. Safety Profile of Bremelanotide Across Clinical Development. J Women's Health. 2022. https://pubmed.ncbi.nlm.nih.gov/35147... 10. Vyleesi Prescribing Information. FDA. 2019. https://www.accessdata.fda.gov/drugsa...