Dr Scott Kopetz Deputy Chair, GI Med Oncology MD Anderson discusses KRAS-directed therapies for CRC скачать в хорошем качестве

Dr Scott Kopetz Deputy Chair, GI Med Oncology MD Anderson discusses KRAS-directed therapies for CRC

In this DocTalk, Dr. Scott Kopetz from MD Anderson talks about the latest on KRAS-directed therapies for colorectal cancer with Dr. Manju George, Scientific Director, Paltown. Timestamp 0:00 Introduction 1:46 : What is adaptive resistance? 3:45 : Lessons learned from BRAF inhibition in CRC 4:16 : Targeting MAPK signaling & adaptive resistance 5:19 : Pathways to resistance 7:33 : KRAS mutations by tumor type 9:00: KRAS G12C inhibition 11:35: Sotorasib in CRC 12:18: Adagrasib in CRC 13:00: Adaptive resistance to KRAS G12C 23:00: How to combat adaptive resistance? 25:45: CodeBreak 101 27:00: Common mechanisms of resistance to G12C inhibitors 28:40: Summary so far 30:04: Combinations with KRAS G12C inhibitors 31:52: Beyond KRAS G12C 33:05: Clinical development of RAS inhibitors 35:19: KRAS G12D inhibitor- preclinical data 39:15: Other approaches 42:49 : Conclusions 45:30 : Q & A