The Smoke That Rewrites the Genome скачать в хорошем качестве

The Smoke That Rewrites the Genome

Tobacco smoke is the most potent systemic mutagen humans routinely encounter, carrying more than 70 carcinogenic chemicals—including PAHs and nitrosamines—that inflict broad genetic injury. Its defining action is the creation of DNA adducts, where reactive compounds bind directly to DNA and lock in permanent mutations in genes such as TP53. Smoking also drives intense oxidative stress, generating reactive oxygen species that produce single strand breaks, double strand breaks, and large scale chromosomal instability. At the same time, it suppresses multiple DNA repair pathways, leaving cells unable to correct the very lesions the smoke induces.