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In 2008, the Italian Vascular surgeon Dr. Paulo Zamboni shocked the world by reporting an association of multiple sclerosis with abnormalities in the veins which drain the brain and spine. In this video, I review the research behind this claim and the results of randomized clinical trials Timestamps 1:36 Background 5:16 Zamboni’s original ultrasound Study 6:22 Zivadinov’s 2011 Study 7:21 Arguments against CCSVI 11:14 Zivadinov’s PREMiSe study 13:18 Zamboni’s BRAVE DREAMS study 17:23 My final thoughts Selected Sources: The central venule sign: https://www.nature.com/articles/nrneu... Superior vena cava syndrome: https://www.ncbi.nlm.nih.gov/books/NB... Multiple sclerosis neuropathology: https://neuropathology-web.org/chapte... BRAVE DREAMS trial: https://jamanetwork.com/journals/jama... Post-hoc analysis of BRAVE-DREAMS: https://journals.sagepub.com/doi/full... Professor gavin giovannoni commentary on CCSVI: https://multiple-sclerosis-research.o... Swedish case series AHSCT in aggressive MS: https://jnnp.bmj.com/content/85/10/1116 Prospective Randomized Endovascular Therapy in MS (PREMiSe): https://www.ncbi.nlm.nih.gov/pmc/arti... Prevalence of CCSVI in MS: https://pubmed.ncbi.nlm.nih.gov/21490... venous hemodynamic insufficiency severity score (VHISS): https://journals.sagepub.com/doi/10.1... Zamboni’s initial publication: https://www.sciencedirect.com/science... Myelin injury may precede immune cell invasion: https://multiplesclerosisnewstoday.co... 2018 commentary on CCSVI: https://www.ncbi.nlm.nih.gov/pmc/arti... Hydration status substantially affects chronic cerebrospinal venous insufficiency assessments: https://www.ncbi.nlm.nih.gov/pmc/arti... subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! My book "Resilience in the Face of Multiple Sclerosis" on Amazon: https://www.amazon.com/dp/B07WP7H5LK Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter: / brandon_beaber Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Видео The video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.