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Join this channel to get access to perks: / @pathologynavigator Download the app “Pathology Simplified” on Play Store to get more resources, learning material, free tests, and much more – https://clpwhite.page.link/79Zy 🔬 Papillary Thyroid Carcinoma (PTC) is the most common thyroid cancer, accounting for nearly 80% of cases worldwide. Its unique hallmark lies in genetic mutations that drive abnormal cell growth, alter signaling pathways, and influence prognosis & therapy. Let’s decode them! ⚡ ✨ Key Mutations in Papillary Thyroid Cancer 1️⃣ BRAF V600E Mutation 🧬 • Found in ~45% of PTC cases. • Activates the MAPK pathway, causing uncontrolled cell division. • Associated with aggressive behavior, higher recurrence, and poorer prognosis. • Strong marker in tall cell variant of PTC. 2️⃣ RET/PTC Rearrangements 🔄 • Fusion of RET tyrosine kinase gene with other partners. • Common in radiation-induced PTC (especially in children after Chernobyl). • Leads to constitutive activation of RET kinase → tumorigenesis. 3️⃣ RAS Mutations 🔥 • Found in follicular variant of PTC. • Activates both MAPK & PI3K pathways. • Less aggressive than BRAF mutation, but still relevant for transformation. 4️⃣ TERT Promoter Mutations 🧾 • Associated with advanced tumors & poor prognosis. • When combined with BRAF V600E, risk of recurrence & metastasis skyrockets. 5️⃣ Other Rare Mutations 🧩 • NTRK fusions (targetable with new drugs). • PIK3CA & AKT mutations (less common, but involved in progression). ⚡ Why are these mutations important? • They guide diagnosis, prognosis, and therapy. • Targeted therapies (like kinase inhibitors) are revolutionizing treatment in advanced PTC. • Genetic profiling = precision medicine for thyroid cancer patients. 💡 Buzzwords to Remember for Exams & Clinics: • BRAF V600E → Aggressive PTC, MAPK pathway • RET/PTC → Radiation, Childhood cancers • RAS → Follicular variant PTC • TERT → Poor prognosis marker Reach out to us for dedicated and individualized pathology coaching – +91 70080 42992(Whatsapp). Regular and 10 days crash course teaching available in pathology for all exams- USMLE, MBBS, NEETPG, INICET, PLAB, MD courses for all countries. Get the best results in pathology with our one-to-one guidance. Like, Subscribe, Share: If you found this information valuable or know someone who might benefit from it, please consider giving this video a thumbs up, subscribing to our channel for more informative content, and sharing this video with your friends and family. Stay informed, stay empowered, and remember, knowledge is a powerful tool for making a difference. 🌐 Stay connected with us and never miss an update: Facebook Page – / pathologynavigator Instagram – / pathologynavigator Twitter – / pathologyshashi LinkedIn – / pathologynavigator Join Our Community WhatsApp Group - https://chat.whatsapp.com/B9yETpriRDt... Facebook Group – / pathologynavigator Thank you for tuning in and joining us on this journey . Knowledge is the first step towards better health! 💙🏥