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Preseptal and orbital cellulitis may look similar at first glance, but confusing the two can have serious consequences. In this video, we walk through how to differentiate preseptal cellulitis from orbital cellulitis, why the orbital septum is the key anatomic divider, and how this distinction directly determines management and urgency. You’ll learn: The anatomy of the orbital septum and why it matters Common causes of preseptal cellulitis, including hordeola, insect bites, and trauma How sinus disease can lead directly to orbital cellulitis Key clinical findings that separate benign from dangerous: Vision changes Proptosis Ophthalmoplegia Chemosis Relative afferent pupillary defect (RAPD) Why orbital cellulitis is a true medical emergency When oral antibiotics are appropriate vs when hospitalization, imaging, and IV antibiotics are required Pediatric considerations, including the risk of deprivation amblyopia We also review real clinical cases, antibiotic choices such as Augmentin and Keflex, and reference American Academy of Ophthalmology (AAO) recommendations to reinforce evidence-based care. This video is ideal for: Optometry and ophthalmology students Eye care professionals Medical trainees Clinicians who want a clear, practical approach to eyelid infections ⚠️ Bottom line: Preseptal cellulitis is common and often manageable. Orbital cellulitis is rare, dangerous, and potentially life-threatening. Knowing the difference saves vision and lives. 👍 Like, subscribe, and follow along as we continue our journey through eyelid anatomy and disease.