Estimating Basal Eurasian Admixture With qpAdm скачать в хорошем качестве

Estimating Basal Eurasian Admixture With qpAdm

Basal Eurasians and Ancestral North Africans (ANA) are two deeply divergent populations that played a foundational role in the genetic makeup of West Eurasian and North African populations. Basal Eurasians are a hypothetical population that split from all other non-Africans before they mixed with Neanderthals. This lineage is thought to have diverged from other Eurasian groups more than 50,000 years ago, possibly in or near the Near East or North Africa. qpAdm is a tool that allows researchers to estimate ancestry proportions in a target population using combinations of source populations (left pops) and outgroups (right pops) to constrain the model. To model Basal Eurasian admixture, especially since there is no direct genome of a "pure" Basal Eurasian individual, I used an indirect method. Including Neanderthal and Denisovan in the right populations (outgroups) allows qpAdm to account for archaic admixture. Since Basal Eurasians had little or no Neanderthal ancestry, any target population showing lower archaic affinity (relative to the epigravettians and Bacho Kiro IUP) can be inferred to have Basal Eurasian admixture. This setup allows qpAdm to detect a ghost population (Basal Eurasian) whose effect is to reduce Neanderthal ancestry in the target. So the key to these models is to include an African group in the lefts, but not use any African anchors in the rights. It is crucial to include neanderthal anchors in the right. Unfortunately, there are no diploid neanderthal groups on the dataset i used, and the first right population has to be a diploid. I found a way to work around that by using Denisova.DG as a right, since it is diploid and closely related to neanderthals. One thing I learned about qpAdm is to never use excessive or unnecessary rights. That’s why I have a different set of rights for populations mixed with east eurasians, such as the indus valley civilization, vs populations that are purely west eurasian, such as Dzudzuana or natufians. Buy Trait Predictor executable here: https://andreikh.itch.io/trait-predictor Buy GWAS health predictor here: https://andreikh.itch.io/gwas-basel-d... Buy Mageplot2025 here: https://andreikh.itch.io/mageplot-202... Buy AndreiDNA services (Qpadm,FST, Custom calc) here: https://docs.google.com/forms/d/e/1FA...