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Immune-mediated inflammatory diseases (IMIDs) and Therapeutic antibodies versus small molecules

Immune-mediated inflammatory diseases (IMIDs) are heterogenous diseases targeting different organs/tissues such as the joints or the skin that often share a common inflammatory pathway. This presentation will give a broad overview of the risk factors for developing IMIDs, their pathogenesis, advanced biologic therapies and how immunogenicity affects response. As with small molecules, there is variability in response to monoclonal antibodies between patients. This presentation will explain how this variability can be studied by analyzing their dose-concentration-effect relationships, the mechanisms of which are different from those of small molecules.