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Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me in Episode #323 as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health. 👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/ Nick Norwitz, PhD is a 28-year-old 4th year medical student at Harvard Medical School. Prior to pursuing a career in medicine, he attended Dartmouth College where he majored in Cell Biology and Biochemistry and graduated Valedictorian. He then went on to complete a PhD at the University of Oxford in Neuro-Metabolism before returning to Boston to complete his MD at Harvard. Personally, Nick practices a ketogenic diet, which he uses therapeutically to treat inflammatory bowel disease. Connect with Nick Norwitz, PhD: Twitter/X: https://x.com/nicknorwitz Instagram: / nicknorwitz YouTube: / @nicknorwitzphd Specifically, we cover: 00:00 - Introduction 02:19 - The Importance of Curiosity in Scientific Progress 06:32 - Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders 22:43 - Scientific and Clinical Impact of the Oreo Study 32:27 - Addressing Criticisms and Misinterpretations of the Study 38:07 - Navigating Statin Discussions on Social Media 50:58 - Debunking Claims About PCSK9 Inhibitors 56:55 - Challenging Misinformation in Health Communities 01:05:39 - The Lipid Energy Model and Lean Mass Hyper Responders Explained 01:12:59 - Defining Lean Mass Hyper Responders: Key Terminology 01:29:15 - Practical Advice for Lean Mass Hyper Responders 01:40:28 - The Carnivore Kid: An Intriguing Case Study 01:44:04 - Personal Struggles with Ulcerative Colitis and Starting Keto 01:49:11 - Balancing Medication and Personal Health Choices 02:09:49 - Debating Dietary Interventions for Inflammatory Bowel Disease 02:24:35 - Challenges in Dietary Research and Medical Interventions 02:33:29 - Introducing the Lipid Energy Model and Its Mechanisms 02:43:09 - Debating the Validity of the Lipid Energy Model 02:51:11 - Long-Term Effects of Ketosis and Carb Restriction 02:55:57 - Critiques and Limitations of the Lipid Energy Model 03:02:30 - ApoB-Containing Lipoproteins and Atherosclerosis 03:05:21 - Current Research and Future Directions on LMHR 03:14:52 - Exploring Inflammatory Responses to Fibre 03:19:29 - The Link Between Saturated Fats and Heart Disease 03:24:09 - Closing Thoughts on Effective Scientific Communication 03:31:12 - The Lean Mass Hyper Responders Debate: Addressing Frustrations 03:45:38 - Understanding Carbohydrate Reintroduction Physiology 03:53:56 - Diet-Specific Strategies to Lower ApoB 04:00:30 - Examining Claims About ApoB and Cardiovascular Disease 04:11:34 - Trade-offs in Lowering ApoB Levels 04:21:22 - Exploring the Link Between All-Cause Mortality and ApoB 04:43:34 - Lean Mass Hyper Responders and ApoB: A Unique Profile 04:46:50 - Concluding Thoughts and Future Discussion Topics This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Head to https://38tera.com and use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to http://eimele.com/ and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on http://join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of http://theproof.com/ and host of The Proof with Simon Hill https://theproof.com/podcast/ Author of The Proof is in the Plants https://theproof.com/book/ Watch the episodes on YouTube / theproofwithsimonhill or listen on Apple https://podcasts.apple.com/au/podcast... / Spotify https://open.spotify.com/show/7bAIJCV... Connect with me on Instagram / theproof , Twitter / theproof , and Facebook / theproofwithsimonhill Nourish your gut with my Plant-Based Ferments Guide https://theproof.com/ferments/ Download my complimentary Two-Week Meal Plan https://plantproof.com/mealplan and high protein Plant Performance recipe book https://theproof.com/performance/