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PERMEOS Electro-Chemotherapy System by Vitalis Technologies, India, is fast emerging as a powerful tool in management of cutaneous and sub-cutaneous cancer tumours. Late detection head and neck cancer tumours and cutaneous and sub-cutaneous metastatic tumours invariably pose a major ‘treatment challenge’. They are often unresponsive to regular treatment modalities of chemotherapy or radiation therapy. Surgery is invariably either not feasible, or difficult, due to their size and location. Overall health condition of the patient can also hinder treatment options. Left with no treatment modalities, such patients would earlier have only one recourse, i.e., to endure. Electro-chemotherapy (ECT) is a new and advanced globally proven tool for management of such tumours. ECT marks a paradigm shift in tumour treatment by offering an effective solution for ‘such difficult to treat tumours’. PERMEOS Tumour Management system is a diligently tested and clinically proven electro-chemotherapy system. Government of India recognises it as a socially important treatment modality. Product development of PERMEOS was supported through the Nidhi Prayas grant from the Government of India.