Hematotoxicity damage to the blood forming tissues by drugs, chemicals, radiation, or diseases скачать в хорошем качестве

Hematotoxicity damage to the blood forming tissues by drugs, chemicals, radiation, or diseases

Hematotoxicity refers to the adverse effects on the blood and blood-forming tissues caused by various factors, including drugs, environmental toxins, radiation, or underlying medical conditions. It can affect the production, function, or lifespan of blood cells, leading to a range of hematological disorders. Mechanisms: Direct Damage: Chemotherapy and radiation therapy can harm hematopoietic stem cells in the bone marrow, impairing blood cell production. Immune-Mediated Effects: Certain drugs or toxins may trigger immune responses that damage blood cells or bone marrow. Secondary Effects: Organ dysfunction (e.g., kidney or liver failure) can indirectly affect hematopoiesis. Clinical Manifestations: Anemia: Reduced red blood cell count, causing fatigue and pallor. Leukopenia: Decreased white blood cell count, increasing infection risk. Thrombocytopenia: Low platelet count, leading to bleeding and bruising. Diagnosis: Blood tests, including complete blood count (CBC), to assess cell counts and morphology. Bone marrow biopsy in severe cases to evaluate hematopoietic function. Management: Drug Withdrawal: Discontinuing the causative agent. Supportive Care: Blood transfusions, growth factor therapy (e.g., erythropoietin or G-CSF), and infection prophylaxis. Treatment of Underlying Conditions: Addressing organ dysfunction or immune disorders. #Hematotoxicity