NRF2 - Dr. Albena Dinkova-Kostova скачать в хорошем качестве

NRF2 - Dr. Albena Dinkova-Kostova

For our fourth episode we will talk about a special system that is very important for protecting the organism against stress: the NRF2 transcription factor. It is the master regulator of the stress response, which is responsible for increasing the expression of a long list of genes that help to combat stress and restore cellular homeostasis. NRF2 is activated by stressful stimuli but also by plant-derived natural compounds, showing how nature has evolved to harness the power of plants to provide benefits for our body. Today we welcome Dr Albena Dinkova-Kostova, a researcher that has greatly contributed to understanding the detailed mechanisms underlying NRF2 activation by different stimuli and is actively engaged in examining the role of NRF2 in metabolism and cancer. Listen on Apple Podcasts https://podcasts.apple.com/us/podcast... Listen on Spotify https://podcasters.spotify.com/pod/sh... #aboutenzymesandmolecules 0:00 - Introduction 3:57 - Regulation of NRF2 by Keap1 7:39 - Keap1 and its cysteine sensors 14:34 - Keap1-NRF2 protein-protein interaction inhibitors 15:07 - Electrophilic NRF2 activators 18:52 - Endogenous electrophilic NRF2 activators 26:24 - Plant-derived NRF2 activators (The ‘mustard oil bomb’) 31:29 - Resveratrol 35:03 - Curcumin 37:51 - Working with Dr Paul Talalay